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Synthesis and Biological Evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide Derivatives as Inhibitors of Entamoeba Histolyica

Afreen Inam, Sonam Mittal, Maitreyi S Rajala, Fernando Avecilla, Amir Azam

Eur J Med Chem. 2016 Nov 29;124:445-455.

PMID: 27598233

Abstract:

In the quest for potent antiamoebic agents, a series of hydrazone hybrids (H1H30) have been designed and sequentially synthesized. The dimethylaminoethoxy and hydrazone entities incorporated into one molecule proved to be more persuasive and selective approach towards designing of antiamoebic agent. The synthesized compounds exhibited promising results against E. histolytica. The compound N'-(2-chlorobenzylidene)-4-(2-(dimethylamino) ethoxy)benzohydrazide was most impending among the series. Cytotoxicity profile showed better cell viability on lung cancer cell line (A549 cells) by MTT assay.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP19353925 4-(Dimethylamino)benzohydrazide 4-(Dimethylamino)benzohydrazide 19353-92-5 Price
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