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Synthesis and Biological Evaluation of 6-carboxy-3,4-methanoprolines, New Rigid Glutamate Analogs

M Marinozzi, B Natalini, M H Ni, G Costantino, R Pellicciari, C Thomsen

Farmaco. 1995 May;50(5):327-31.

PMID: 7626167

Abstract:

6-Carboxy-3,4-methanoprolines were prepared by reacting ethyl diazoacetate with the suitable 3,4-didehydroproline derivative in the presence of rhodium(II)acetate dimer as catalyst. The affinities of the title compounds for displacement of receptor binding to ionotropic and metabotropic (mGluR1 alpha) glutamate receptors were also determined.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP15956282 Rhodium(II) acetate dimer Rhodium(II) acetate dimer 15956-28-2 Price
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