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Synthesis and Biological Evaluation of Nitric Oxide Releasing Derivatives of 6-amino-3-n-butylphthalide as Potential Antiplatelet Agents

Xiaoli Wang, Linna Wang, Zhangjian Huang, Xiao Sheng, Tingting Li, Hui Ji, Jinyi Xu, Yihua Zhang

Bioorg Med Chem Lett. 2013 Apr 1;23(7):1985-8.

PMID: 23481646

Abstract:

A series of novel nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide were designed, synthesized and evaluated as potential antiplatelet agents. Compound 10b significantly inhibited the adenosine diphosphate (ADP)-induced platelet aggregation in vitro, superior to 6-amino-3-n-butylphthalide, 3-n-butylphthalide (NBP) and ticlopidine. Meanwhile 10b released moderate levels of NO, which could be beneficial for improving cardiovascular and cerebral circulation. Furthermore, 10b had an enhanced aqueous solubility relative to NBP. These findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP68559604 Ticlopidine Related Compound A Ticlopidine Related Compound A 68559-60-4 Price
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