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Synthesis and Carbonic Anhydrase Activating Properties of a Series of 2-amino-imidazolines Structurally Related to Clonidine

Synthesis and Carbonic Anhydrase Activating Properties of a Series of 2-amino-imidazolines Structurally Related to Clonidine

Niccolò Chiaramonte, Soumia Maach, Caterina Biliotti, Andrea Angeli, Gianluca Bartolucci, Laura Braconi, Silvia Dei, Elisabetta Teodori, Claudiu T Supuran, Maria Novella Romanelli

J Enzyme Inhib Med Chem. 2020 Dec;35(1):1003-1010.

PMID: 32336172

Abstract:

The Carbonic Anhydrase (CA, EC 4.2.1.1) activating properties of histamine have been known for a long time. This compound has been extensively modified but only in few instances the imidazole ring has been replaced with other heterocycles. It was envisaged that the imidazoline ring could be a bioisoster of the imidazole moiety. Indeed, we report that clonidine, a 2-aminoimidazoline derivative, was found able to activate several human CA isoforms (hCA I, IV, VA, VII, IX, XII and XIII), with potency in the micromolar range, while it was inactive on hCA II. A series of 2-aminoimidazoline, structurally related to clonidine, was then synthesised and tested on selected hCA isoforms. The compounds were inactive on hCA II while displayed activating properties on hCA I, VA, VII and XIII, with KA values in the micromolar range. Two compounds (10 and 11) showed some preference for the hCA VA or VII isoforms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP54707710	Clonidine Related Compound A		54707-71-0	Price

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