Home
Resources
Publications
Synthesis and Characterization of Amphiphilic Block Polymer Poly(ethylene Glycol)-Poly(propylene Carbonate)-Poly(ethylene Glycol) for Drug Delivery

Synthesis and Characterization of Amphiphilic Block Polymer Poly(ethylene Glycol)-Poly(propylene Carbonate)-Poly(ethylene Glycol) for Drug Delivery

Hongchun Li, Yongsheng Niu

Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:160-165.

PMID: 29752085

Abstract:

A novel amphiphilic block polymer poly(ethylene glycol)-poly(propylene carbonate)-poly(ethylene glycol) (PEG-PPC-PEG) was synthesized via the dicyclohexylcarbodiimide condensation reaction of double PEG-bis-amine and HOOC-PPC-COOH. The obtained copolymer was characterized by NMR to determine its structure. Using the PEG-PPC-PEG as the carrier and using doxorubicin (DOX) as a model drug, DOX-loaded nanoparticles with core shell structure were synthesized by self-assembly in water. The nanoparticles properties such as particle size, drug loading, encapsulation efficiency (EE) and drug release behavior were investigated as a function of the hydrophobic block length of PPC segments and compared with each other. The results showed that the EE was up to 88.8%. Nanoparticles were found to have a certain effect on the controlled release of DOX.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24991535	Poly(ethylene glycol) bis(amine)		24991-53-5	Price
AP25511857	Poly(propylene carbonate)		25511-85-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: