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Synthesis and Characterization of Multifunctional Fe3O4/poly(fluorescein O-methacrylate) core/shell Nanoparticles

Synthesis and Characterization of Multifunctional Fe3O4/poly(fluorescein O-methacrylate) core/shell Nanoparticles

Patakamuri Govindaiah, Taewon Hwang, Hyunhee Yoo, Yong Seok Kim, Sun Jong Lee, Sung Wook Choi, Jung Hyun Kim

J Colloid Interface Sci. 2012 Aug 1;379(1):27-32.

PMID: 22613627

Abstract:

Multifunctional fluorescent and superparamagnetic Fe(3)O(4)/poly(fluorescein O-methacrylate) [Fe(3)O(4)/poly(FMA)] nanoparticles with core/shell structure were synthesized via surface-initiated polymerization. First, polymerizable double bonds were introduced onto the surface of Fe(3)O(4) nanoparticles via ligand exchange and a condensation reaction. A fluorescent monomer, FMA, was then polymerized to the double bonds at the surface via free-radical polymerization, leading to form a fluorescent polymer shell around the superparamagnetic Fe(3)O(4) core. The resultant Fe(3)O(4)/poly(FMA) nanoparticles were characterized by Fourier transform infrared, nuclear magnetic resonance, and X-ray diffraction spectroscopy to confirm the reactions. Transmission electron microscopy images showed that the Fe(3)O(4)/poly(FMA) nanoparticles have a spherical and monodisperse core/shell morphology. Photoluminescence spectroscopy and superconducting quantum interference device magnetometer analyses confirmed that the Fe(3)O(4)/poly(FMA) nanoparticles exhibited fluorescent and superparamagnetic properties, respectively. In addition, we demonstrated the potential bioimaging application of the Fe(3)O(4)/poly(FMA) nanoparticles by visualizing the cellular uptake of the nanoparticles into A549 lung cancer cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP480439154	Fluorescein O-methacrylate		480439-15-4	Price
LS775184	Poly(fluorescein O-methacrylate)			Price

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