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Synthesis and Characterization of Novel Biodegradable Poly(carbonate Ester)s With Photolabile Protecting Groups

Synthesis and Characterization of Novel Biodegradable Poly(carbonate Ester)s With Photolabile Protecting Groups

Zhigang Xie, Xiuli Hu, Xuesi Chen, Jing Sun, Quan Shi, Xiabin Jing

Biomacromolecules. 2008 Jan;9(1):376-80.

PMID: 18067260

Abstract:

Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-MCC)) was obtained by UV irradiation of poly(L-lactide acid-co-5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one) (P(LA-co-MNC)) to remove the protective 2-nitrobenzyl group. The free carboxyl groups on the copolymers P(LA-co-MCC) were reacted with paclitaxel, a common antitumor drug. Gel permeation chromatography and NMR studies confirmed the copolymer structures and successful attachment of paclitaxel to the copolymer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74313	Poly(L-lactide-co-5-methyl-5-allyloxycarbonyl-1,3-dioxan- 2-one)			Price

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