Home
Resources
Publications
Synthesis and Characterization of Salicylic Acid-Based Poly(Anhydride-Ester) Copolymers

Synthesis and Characterization of Salicylic Acid-Based Poly(Anhydride-Ester) Copolymers

Robert C Schmeltzer, Kathryn E Uhrich

J Bioact Compat Polym. 2006 Mar;21(2):123-133.

PMID: 23956492

Abstract:

A series of poly(anhydride-esters) based on poly(1,10-bis(o-car-boxyphenoxy)decanoate) (CPD) and poly(1,6-bis(p-carboxyphenoxy)hexane) (p-CPH) were synthesized by melt-condensation polymerization. Poly-(anhydride-esters) that contain CPD hydrolytically degraded into salicylic acid, however, these homopolymers have mechanical and thermal characteristics that limit their use in clinical applications. The synthesis and characterization of copolymers of CPD with p-CPH, a monomer known to generate mechanically stable homopolymers, was investigated. By changing the CPD to p-CPH monomer ratios, the salicylic acid loading and thermal/mechanical properties of the copolymers was a controlling factor; increasing the CPD concentration increased the salicylate loading but decreased the polymer stability; whereas increasing the p-CPH concentration increased the thermal and mechanical stability of the copolymers. Specifically, decreasing the CPD:p-CPH ratio resulted in lower salicylate loading and increased thermal decomposition temperatures. The glass transition temperatures (°C) varied from 27 to 38°C, a desirable range for elastomeric biomedical implants.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS743148	Poly[1,6-bis(p-carboxyphenoxy)hexane]			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: