0

Synthesis and Evaluation of Compounds That Induce Readthrough of Premature Termination Codons

Michael E Jung, Jin-Mo Ku, Liutao Du, Hailiang Hu, Richard A Gatti

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5842-8.

PMID: 21873052

Abstract:

A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1359825947 RTC13 RTC13 1359825-94-7 Price
qrcode