Home
Resources
Publications
Synthesis and Fungicidal Activity of Novel Pimprinine Analogues

Synthesis and Fungicidal Activity of Novel Pimprinine Analogues

Ming-Zhi Zhang, Qiong Chen, Nick Mulholland, David Beattie, Dianne Irwin, Yu-Cheng Gu, Guang-Fu Yang, John Clough

Eur J Med Chem. 2012 Jul;53:283-91.

PMID: 22560632

Abstract:

A simple and efficient synthetic protocol for 5-(3-indolyl)-oxazoles has been developed and further used to synthesize a series of novel analogues of natural product pimprinine. All new compounds were identified by (1)H NMR, high resolution mass spectrometry, and the structures of 10 and 18o were further confirmed by X-ray crystallographic diffraction analysis. Bioassay conducted at Syngenta showed that several of the synthesized compounds exhibited fungicidal activity. Compounds 10, 17, 18 h, 18o, 19 h, 19i and 19 l all showed effective control of three out of the seven tested phytopathogenic fungi at the highest rate screened. Compounds 17 and 19 h in particular showed activity against the four pathogens screened in artificial media; Pythium dissimile, Alternaria solani, Botryotinia fuckeliana and Gibberella zeae.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13640261	Pimprinine		13640-26-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: