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Synthesis and Medicinal Chemistry of Muraymycins, Nucleoside Antibiotics

Synthesis and Medicinal Chemistry of Muraymycins, Nucleoside Antibiotics

Akira Katsuyama, Satoshi Ichikawa

Chem Pharm Bull (Tokyo). 2018;66(2):123-131.

PMID: 29386462

Abstract:

Muraymycins, isolated from a culture broth of Streptomyces sp., are members of a class of naturally occurring nucleoside antibiotics. They are strong inhibitors of the phospho-MurNAc-pentapeptide translocase (MraY), which is responsible for the peptidoglycan biosynthesis. Since MraY is an essential enzyme among bacteria, muraymycins are expected to be a novel antibacterial agent. In this review, our efforts to synthesize muraymycin D2, simplify the chemical structure, improve antibacterial spectrum, and solve the X-ray crystal structure of the muraymycin D2/MraY complex are described.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741330	Peptidoglycan from Streptomyces sp.			Price

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