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Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors

Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors

Abd El-Galil E Amr, Mohamed F El-Shehry, Alhussein A Ibrahim, Hanaa M Hosni, Mohamed A Al-Omar, Hazem A Ghabbour

Mini Rev Med Chem. 2019;19(10):833-841.

PMID: 30760188

Abstract:

Background & objective:
A series of novel derivatives possessing the thiophene moiety were synthesized using ethyl 5'-amino-2,3'-bithiophene-4'-carboxylate as the starting material.
Methods:
The new synthesized derivatives were screened as lactate dehydrogenase (LDH) inhibitors. LDH plays an important role in glucose metabolism in cancer cells and can affect tumor genesis and metastasis.
Results:
3-Substituted p-tolylthieno[2,3-d]pyrimidin-4(3H)-ones 4 were the most potent inhibitors in this study compared to Galloflavin reference drug.
Conclusion:
Molecular docking studies on the Human Lactate Dehydrogenase active site were carried out on the synthesized compounds and the MolDock scores ranged between -127 to -171.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2404899	2,3′-Bithiophene		2404-89-9	Price

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