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Synthesis and Pharmacological Evaluation of Sulfamide-Based Analogues of Anandamide

Carolina Cano, Juan Antonio Páez, Pilar Goya, Antonia Serrano, Javier Pavón, Fernando Rodríguez de Fonseca, Margarita Suardíaz, María Isabel Martín

Eur J Med Chem. 2009 Dec;44(12):4889-95.

PMID: 19762126

Abstract:

Arachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimimetic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide moiety of anandamide by -CH(2)NHSO(2)NH-R considerably reduces the CB1 receptor activity and only some of the compounds showed modest cannabinoid properties in binding assays. The new compounds were also tested as inhibitors of the FAAH enzyme but were inactive.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP68171528 Linoleyl ethanolamide Linoleyl ethanolamide 68171-52-8 Price
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