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Synthesis and Pharmacological Studies of Unprecedented Fused Pyridazino[3',4':5,6][1,2,4]triazino[3,4- b][1,3,4]thiadiazine Derivatives

Synthesis and Pharmacological Studies of Unprecedented Fused Pyridazino[3',4':5,6][1,2,4]triazino[3,4- b][1,3,4]thiadiazine Derivatives

Rania S Ali, Hosam A Saad

Molecules. 2018 Apr 27;23(5):1024.

PMID: 29702549

Abstract:

A novel fused system with three or four fused rings-pyridazino[3',4':5,6][1,2,4]triazino[4,3-b][1,2,4,5]tetrazine and pyridazino[3',4':5,6][1,2,4]triazino[3,4-b]pyrimido[4,5-e][1,3,4]thiadiazine was obtained from the starting materials 4(6H)-amino-3-hydrazino-7-(2-thienyl)pyridazino[3,4-e][1,2,4]-triazine 2 and 9-amino-3-(2-thienyl)-2H,8H-pyridazino[3',4':5,6][1,2,4]triazino[3,4-b][1,3,4]thiadiazine-8-carbonitrile 12. Each of the starting compounds was subjected to a number of cyclization reactions to obtain a series of new heterocyclic fused systems, 3⁻10 and 13⁻23, via bifunctional reagents. Some of the synthesized compounds were screened against three cell lines including HepG2, HCT-116 and MCF-7 to discover their anticancer activity. The synthesized compounds were characterized depending on their elemental analyses and spectral data.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1173018795	1,7-Dimethylxanthine-2,4,5,6-13C4-1,3,9-15N3		1173018-79-5	Price

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