Home
Resources
Publications
Synthesis and Phase Behavior of Poly( N-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly( N-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride)

Synthesis and Phase Behavior of Poly( N-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly( N-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride)

Milica Spasojević, Joop Vorenkamp, Mark R P A C S Jansen, Paul de Vos, Arend Jan Schouten

Materials (Basel). 2014 Jul 22;7(7):5305-5326.

PMID: 28788130

Abstract:

The synthesis of poly(N-isopropylacrylamide)-b-poly(L-lysine) and poly(N- isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of N-isopropylacrylamide yielded narrowly dispersed polymers with consistent high yields (~80%). Lower yields (~50%) were observed when narrowly dispersed random copolymers of N-isopropylacrylamide and acrylamide where synthesized. Amino-terminated poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide- co-acrylamide) were successfully used as macroinitiators for ROP of N₆-carbobenzoxy-L- lysine N-carboxyanhydride. The thermal behavior of the homopolymers and copolymers in aqueous solutions was studied by turbidimetry, dynamic light scattering (DLS) and proton nuclear magnetic resonance spectroscopy (¹H-NMR).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26124787	Poly-L-lysine hydrochloride		26124-78-7	Price
AP657272-B	L-Lysine hydrochloride		657-27-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: