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Synthesis and Reactions of 2-Carboxyvinyl-4-chloro-6,8-dibromoquinazoline and Some New Fused Triazolo-Quinazoline Derivatives

Synthesis and Reactions of 2-Carboxyvinyl-4-chloro-6,8-dibromoquinazoline and Some New Fused Triazolo-Quinazoline Derivatives

Yaser Abdel-Moemen El-Badry

Acta Chim Slov. 2010 Dec;57(4):836-41.

PMID: 24061885

Abstract:

Synthesis of 2-carboxyvinyl-4-chloro-6,8-dibromoquinazoline (2) has been achieved via chlorination of the corresponding 6,8-dibromoquinazoline analog. The simple replacement of the chlorine atom at the position 4 of quinazoline nucleus with different amines has produced derivatives of the 4-heteroarylquinazoline and the fused quinazolino[4,3-c]quinazoline. The reaction of the chloroquinazoline derivative 2 with hydrazine hydrate and subsequent condensation with different aromatic aldehydes furnished a series of fused 5-substituted-[1,2,4]triazoloquinazoline derivatives. Finally, its reaction with acyl hydrazide (acetyl hydrazide) furnished the heterocyclic system 7,9-dibromo-3-methyl-[1,2,4]triazolo[4,3-c]Quinazolin-5-yl-2-propenoic acid.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6166865	2,4,6,8,10-Pentamethylcyclopentasiloxane		6166-86-5	Price

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