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Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), Produced by Dictyostelium Discoideum

Chihiro Murata, Tetsuhiro Ogura, Shuhei Narita, Anna P Kondo, Natsumi Iwasaki, Tamao Saito, Toyonobu Usuki

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1428-33.

PMID: 26832786

Abstract:

4-Methyl-5-pentylbenzene-1,3-diol (MPBD) is a secondary metabolite of SteelyA polyketide synthase, which controls cell aggregation and spore maturation of Dictyostelium discoideum. In this study, chemical synthesis of MPBD and its derivatives was achieved. Structure-activity relationship (SAR) studies for antimicrobial activities against Escherichia coli and Bacillus subtilis were also conducted.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP538681 Pentylbenzene Pentylbenzene 538-68-1 Price
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