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Synthesis and SAR Study of Novel Sarsasapogenin Derivatives as Potent Neuroprotective Agents and NO Production Inhibitors

Synthesis and SAR Study of Novel Sarsasapogenin Derivatives as Potent Neuroprotective Agents and NO Production Inhibitors

Hui Pan, Pham Van Khang, Dong Dong, Rui Wang, Lei Ma

Bioorg Med Chem Lett. 2017 Feb 1;27(3):662-665.

PMID: 27919659

Abstract:

Sarsasapogenin, isolated from rhizomes of Anemarrhena asphodeloides, was found to be able to enhance memory. On the basis of the structure of Sarsasapogenin, a series of derivatives were synthesized and evaluated for their neuroprotective activity in PC12 cells and NO production inhibitory activity in RAW264.7 cell lines. The preliminary structure-activity relationship of them indicated that introduction of carbamate groups at the 3-hydroxyl position of sarsasapogenin might improve neuroprotective activity. Some synthesized derivatives such as AA3, AA4, AA9 and AA13 exhibited both notably neuroprotective activity and NO production inhibitory activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP126192	Sarsasapogenin		126-19-2	Price

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