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Synthesis of 4-arylpiperidines From 1-benzyl-4-piperidone: Application of the Shapiro Reaction and Alkenylsilane Cross-Coupling

Christie Morrill, Neelakandha S Mani

Org Lett. 2007 Apr 12;9(8):1505-8.

PMID: 17362023

Abstract:

[reaction: see text] 1-Benzyl-3,4-unsaturated-4-piperidinyl benzyldimethylsilane has been prepared and observed to readily undergo palladium-catalyzed cross-coupling reactions with a variety of aryl iodides and aryl bromides to generate 3,4-unsaturated 4-arylpiperidines, often at ambient temperature.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1631705 Benzyldimethylsilane Benzyldimethylsilane 1631-70-5 Price
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