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Synthesis of 4-quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source

Synthesis of 4-quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source

Linda Åkerbladh, Patrik Nordeman, Matyas Wejdemar, Luke R Odell, Mats Larhed

J Org Chem. 2015 Feb 6;80(3):1464-71.

PMID: 25575042

Abstract:

A palladium-catalyzed CO gas-free carbonylative Sonogashira/cyclization sequence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two different protocols is described. The first method (A) yields the cyclized products after only 20 min of microwave (MW) heating at 120 °C. The second method (B) is a gas-free one-pot two-step sequence which runs at room temperature, allowing the use of sensitive substituents (e.g., nitro and bromide groups). For both protocols, molybdenum hexacarbonyl was used as a solid source of CO.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13939065	Molybdenumhexacarbonyl		13939-06-5	Price

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