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Synthesis of 8-aminoadenosine 5'-(aminoalkyl Phosphates), Analogues of Aminoacyl Adenylates

Esmail Yousefi-Salakdeh, Merita Murtola, Anders Zetterberg, Esther Yeheskiely, Roger Strömberg

Bioorg Med Chem. 2006 Apr 15;14(8):2653-9.

PMID: 16368242

Abstract:

A short and efficient route for the synthesis of aminoalkyl 8-aminoadenylates, potential aminoacyl-tRNA synthetase inhibitors, is presented. Aminoalkyl 8-aminoadenylates were synthesized using a 5'-H-phosphonate strategy involving minimal protecting group manipulations and a single final deprotection step.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3868335 8-Aminoadenosine 8-Aminoadenosine 3868-33-5 Price
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