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Synthesis of 8-geranyloxypsoralen Analogues and Their Evaluation as Inhibitors of CYP3A4

Synthesis of 8-geranyloxypsoralen Analogues and Their Evaluation as Inhibitors of CYP3A4

E C Row, S A Brown, A V Stachulski, M S Lennard

Bioorg Med Chem. 2006 Jun 1;14(11):3865-71.

PMID: 16481174

Abstract:

Furanocoumarins have been shown to inhibit CYP3A4 in vitro with varying degrees of potency. In this study, we report the effects of a series of novel furanocoumarins based on the naturally occurring derivative 8-geranylepoxypsoralen which has been shown to be a more potent inhibitor of CYP3A4 than its 5-position-substituted counterpart bergamottin. Compounds were designed, synthesised and tested for their ability to inhibit CYP3A4 activity in human liver microsomes using testosterone as the marker substrate. Both the saturated and unsaturated phenolic furanocoumarin derivatives were found to be inactive. However, the 8-alkyloxy-furanocoumarin analogues were shown to inhibit CYP3A4 activity in a dose dependent manner, with IC(50) values ranging from 0.78+/-0.11 to 3.93+/-0.53 microM. The reduced furan derivative dihydro-8-geranyloxypsoralen showed a 4-fold decrease in inhibitory potency, suggesting that the furan moiety plays a role in the interaction between these compounds and CYP3A4.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7437550	8-Geranyloxypsoralen		7437-55-0	Price

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