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Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents

Rabya Munawar, Nousheen Mushtaq, Sadia Arif, Ahsaan Ahmed, Shamim Akhtar, Sumaira Ansari, Sadia Meer, Zafar S Saify, Muhammad Arif

Am J Alzheimers Dis Other Demen. 2016 May;31(3):263-9.

PMID: 26385945

Abstract:

In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer's disease. All derivatives showed better inhibition of enzymes than the standard galantamine, whereas except RM4, all exhibit better results than tacrine, a well-known acridine derivative used for the treatment of Alzheimer's disease.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP90459 9-Aminoacridine 9-Aminoacridine 90-45-9 Price
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