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Synthesis of a Masked 2,3-Diaminoindole

Philip Z Mannes, Evans O Onyango, Gordon W Gribble

J Org Chem. 2016 Dec 16;81(24):12478-12481.

PMID: 27978742

Abstract:

A three-step synthesis of masked 2,3-diaminoindole 1 from 2-iodo-3-nitro-1-(phenylsulfonyl)indole (2) has been developed. Treatment of 1 with trifluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapped with α-dicarbonyl compounds to afford 5H-pyrazino[2,3-b]indoles 7-10.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP129271983 1-(Phenylsulfonyl)-3-indolylboronic acid 1-(Phenylsulfonyl)-3-indolylboronic acid 129271-98-3 Price
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