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Synthesis of Benzyl Cinnamate by Enzymatic Esterification of Cinnamic Acid

Synthesis of Benzyl Cinnamate by Enzymatic Esterification of Cinnamic Acid

Yun Wang, Dong-Hao Zhang, Na Chen, Gao-Ying Zhi

Bioresour Technol. 2015 Dec;198:256-61.

PMID: 26398669

Abstract:

In this study, lipase catalysis was successfully applied in synthesis of benzyl cinnamate through esterification of cinnamic acid with benzyl alcohol. Lipozyme TLIM was found to be more efficient for catalyzing this reaction than Novozym 435. In order to increase the yield of benzyl cinnamate, several media, including acetone, trichloromethane, methylbenzene, and isooctane, were used in this reaction. The reaction showed a high yield using isooctane as medium. Furthermore, the effects of several parameters such as water activity, reaction temperature, etc, on this reaction were analyzed. It was pointed out that too much benzyl alcohol would inhibit lipase activity. Under the optimum conditions, lipase-catalyzed synthesis of benzyl cinnamate gave a maximum yield of 97.3%. Besides, reusable experiment of enzyme demonstrated that Lipozyme TLIM retained 63% of its initial activity after three cycles. These results were of general interest for developing industrial processes for the preparation of benzyl cinnamate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103413	Benzyl cinnamate		103-41-3	Price

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