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Synthesis of BMS-309403-related Compounds, Including [¹⁴C]BMS-309403, a Radioligand for Adipocyte Fatty Acid Binding Protein

Synthesis of BMS-309403-related Compounds, Including [¹⁴C]BMS-309403, a Radioligand for Adipocyte Fatty Acid Binding Protein

Toshihiko Okada, Makoto Hiromura, Masato Otsuka, Shuichi Enomoto, Hiroyuki Miyachi

Chem Pharm Bull (Tokyo). 2012;60(1):164-8.

PMID: 22223390

Abstract:

Adipocyte fatty acid binding protein (A-FABP; FABP4), which is predominantly expressed in macrophages and adipose tissue, regulates fatty acid storage and lipolysis, and is also an important mediator of inflammation. Here, we report a synthesis of (14)C-labeled 2-[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy]acetic acid (BMS309403), a potent and selective small-molecular FABP4 inhibitor, as a chemical tool for investigating the roles of FABP4 in inflammatory and metabolic disorders. The structure-activity relationship of several BMS derivatives for inhibition of FABP4 is also reported.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP300657038	BMS-309403		300657-03-8	Price

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