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Synthesis of Compounds Related to the Anti-Migraine Drug Eletriptan Hydrobromide

Synthesis of Compounds Related to the Anti-Migraine Drug Eletriptan Hydrobromide

Suri Babu Madasu, Nagaji Ambabhai Vekariya, M N V D Hari Kiran, Badarinadh Gupta, Aminul Islam, Paul S Douglas, Korupolu Raghu Babu

Beilstein J Org Chem. 2012;8:1400-5.

PMID: 23019477

Abstract:

Eletriptan hydrobromide (1) is a selective serotonin (5-HT(1)) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC-MS. To control the formation of these impurities during the preparation of active pharmaceutical ingredients, the structure of the impurities must be known. Major impurities of the eletriptan hydrobromide synthesis were prepared and characterized by using various spectroscopic techniques, i.e., mass spectroscopy, FTIR , (1)H NMR, (13)C NMR/DEPT, and further confirmed by co-injection in HPLC. The present study will be of great help in the synthesis of highly pure eletriptan hydrobromide related compounds.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31041402	Eletriptan Hydrobromide			Price

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