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Synthesis of cynaropicrin-d(4)

Takuya Sato, Shihori Hara, Makiko Sato, Keita Ogawa, Michael Adams, Toyonobu Usuki

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5504-7.

PMID: 26520660

Abstract:

Cynaropicrin is a guaianolide sesquiterpene lactone, which has potent in vitro and in vivo inhibitory activity against Trypanosoma brucei, the protozoan parasite that causes human African trypanosomiasis (HAT; sleeping sickness). Herein, we describe the synthesis of cynaropicrin's deuterated derivative, cynaropicrin-d4, by the replacement of the side chain of natural cynaropicrin. The synthesized cynaropicrin-d4 could be employed as an internal standard for liquid chromatography-mass spectrometry (LC-MS) analysis, in the pharmacokinetic study of cynaropicrin. This could potentially advance the study of this therapeutic lead.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP35730780 Cynaropicrin Cynaropicrin 35730-78-0 Price
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