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Synthesis of Deuterium-Labeled 2-quinoxalinecarboxylic Acid and 3-methylquinoxaline-2-carboxylic Acid From Deuterium Aniline

Wulian Chen, Chaomin Zhao, Xiaojun Deng

J Labelled Comp Radiopharm. 2018 Dec;61(14):1043-1047.

PMID: 30132955

Abstract:

An efficient and simple synthetic route of deuterium-labeled 2-quinoxalinecarboxylic acid-d4 (QCA-d4 ) and 3-methylquinoxaline-2-carboxylic acid-d4 (MQCA-d4 ) is presented with 99.9% and 99.6% isotopic enrichment using aniline-d5 as labeled starting material. Their chemical structures were confirmed by 1 H NMR, and their isotopic abundance was determined by mass spectrometry analysis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP107099990 2,5-Dimethoxyphenylboronic acid 2,5-Dimethoxyphenylboronic acid 107099-99-0 Price
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