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Synthesis of Functionalized 1,2-dihydroisoquinolines via Multicomponent One-Pot Reaction of 2-alkynylbenzaldehyde, Amine, Zinc, and Allylic Bromide or Benzyl Bromide

Ke Gao, Jie Wu

J Org Chem. 2007 Oct 26;72(22):8611-3.

PMID: 17919003

Abstract:

A multicomponent one-pot reaction of 2-alkynylbenzaldehydes, amines, zinc, and allylic bromide or benzyl bromide using the combination of Mg(ClO4)2/Cu(OTf)2 as catalyst in THF/DCE (1:20) is described, which provides an efficient and practical route for the synthesis of functionalized 1,2-dihydroisoquinolines.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP21450908 2-Methyl-1-naphthylmagnesium bromide 2-Methyl-1-naphthylmagnesium bromide 21450-90-8 Price
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