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Synthesis of Functionalized Chromene and Chroman Derivatives via Cesium Carbonate Promoted Formal [4 + 2] Annulation of 2'-Hydroxychalcones With Allenoates

Hossein Rouh, Yangxue Liu, Nandakumar Katakam, Lilian Pham, Yi-Long Zhu, Guigen Li

J Org Chem. 2018 Dec 21;83(24):15372-15379.

PMID: 30481026

Abstract:

A new strategy has been established for the synthesis of functionalized chromene and chroman derivatives via a Cs2CO3-catalyzed domino addition of 2'-hydroxychalcone derivatives with allenoates, which can serve as a general avenue for the construction of multireplaced chromene derivatives. Chemoselectivity of this synthesis was found to depend on substituents on substrates. Good to excellent yields were achieved under simple and mild conditions at room temperature.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP534178 Cesium carbonate Cesium carbonate 534-17-8 Price
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