Home
Resources
Publications
[Synthesis of N-alpha-(arylsulfonyl-L-prolyl)- And N alpha-(benzyloxycarbonyl-L-prolyl)-D,L-4-amidinophenylalanine Amides as Inhibitors of Thrombin]

[Synthesis of N-alpha-(arylsulfonyl-L-prolyl)- And N alpha-(benzyloxycarbonyl-L-prolyl)-D,L-4-amidinophenylalanine Amides as Inhibitors of Thrombin]

B Voigt, G Wagner

Pharmazie. 1986 Apr;41(4):233-5.

PMID: 3725864

Abstract:

N alpha substituted 4-cyanophenylalanines were prepared by reaction of the acid chloride, the activated ester and the mixed anhydride of Tos-Pro-OH, 2-naphthylsulfonyl-L-proline and Z-Pro-OH, respectively, with cyanophenylalanine. These acids were transferred into the amides via the 4-nitrophenyl esters or the mixed anhydrides. The cyano compounds were converted via the thioamides and the thioimidic esters into the amidines by common way. The exchange of the glycine residue by prolin in compounds former described caused a decreased antithrombin effect.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP159717687	N-(7-Nitro-4-benzofurazanyl)-L-prolyl chloride		159717-68-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: