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Synthesis of Nanosized Chitosan-Poly(acrylic Acid) Particles by a Dropping Method

Synthesis of Nanosized Chitosan-Poly(acrylic Acid) Particles by a Dropping Method

Tao-Chih Chang, Jian-Wen Wang, Min-Hsiung Hon

Macromol Biosci. 2004 Apr 19;4(4):416-20.

PMID: 15468233

Abstract:

Deoxyribonucleic acid (DNA) vaccines are being investigated extensively because of their excellent potential over conventional protein ones. A suitable DNA carrier, consisting of uniformly dispersed chitosan-poly(acrylic acid) particles with an average size of 30 nm, was successfully synthesized by a dropping method with a ratio of chitosan solution to poly(acrylic acid) solution of 1:1 and was incubated in a buffer solution with a pH value of 3.0. The particle size increased from 35.76 to 45.90 nm when the pH value of the buffer solution was increased from 3.0 to 7.4. After freeze-drying, the non-incubated mixed solution showed a membranous morphology. A powdered product was formed from the mixed solution as incubated in buffer solution with pH values of 3.0 and 5.3. However, when the mixed solution was incubated in a buffer solution of pH 7.4, a mixture of membrane and powder was obtained.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9003014-A	Poly(acrylic acid) solution		9003-01-4	Price

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