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Synthesis of Novel Derivatives of Esculentoside A and Its Aglycone Phytolaccagenin, and Evaluation of Their Haemolytic Activity and Inhibition of Lipopolysaccharide-Induced Nitric Oxide Production

Wei Gong, Zhihui Jiang, Peng Sun, Ling Li, Yongsheng Jin, Lucheng Shao, Wen Zhang, Baoshu Liu, Hongwei Zhang, Hua Tang, Yufeng Chen, Yanghua Yi, Dazhi Zhang

Chem Biodivers. 2011 Oct;8(10):1833-52.

PMID: 22006712

Abstract:

A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structure-activity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS-induced NO production, and lower haemolytic activities than esculentoside A and its derivatives.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1802126 Phytolaccagenin Phytolaccagenin 1802-12-6 Price
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