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Synthesis of Some New 2-(6-methoxy-2-naphthyl)- 5-aryl-1,3,4-oxadiazoles as Possible Non-Steroidal Anti-Inflammatory and Analgesic Agents

Synthesis of Some New 2-(6-methoxy-2-naphthyl)- 5-aryl-1,3,4-oxadiazoles as Possible Non-Steroidal Anti-Inflammatory and Analgesic Agents

Badiadka Narayana, Kuniyil Kulangara Vijaya Raj, Badiadka Valamale Ashalatha, Nalilu Suchetha Kumari

Arch Pharm (Weinheim). 2005 Aug;338(8):373-7.

PMID: 16041838

Abstract:

The synthesis of some new 2-(6-methoxy-2-naphthyl)-5-aryl-1,3,4-oxadiazoles (4a-k) has been described. Ethyl-6-methoxy-2-naphthoate (1) yielded on treatment with hydrazine hydrate to 6-methoxy-2-naphthoic acid hydrazide (2). Compound 2 reacted with substituted aromatic carboxylic acids (3a-k) in phosphorus oxychloride yielded 2-(6-methoxy-2-naphthyl)-5-aryl-1,3,4-oxadiazoles (4a-k). Newly synthesized compounds were characterized by IR, (1)H-NMR and mass spectral data. All the compounds were screened for their anti-inflammatory and analgesic activity. Compound 4j exhibited promising anti-inflammatory and analgesic activities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2471707-A	6-Methoxy-2-naphthoic acid		2471-70-7	Price

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