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Synthesis of Some New Pyrazole and Pyrimidine Derivatives Carrying a Sulfonamide Moiety of Expected Antitumor Activity and Study of the Synergistic Effect of Gamma-Irradiation

Mostafa M Ghorab, Fatma A Ragab, Helmy I Heiba, Hanan A Youssef, Marwa Galal

Arzneimittelforschung. 2010;60(1):48-55.

PMID: 20184227

Abstract:

Several novel pyrazole (11-18) and pyrimidine (19-23) derivatives were synthesized starting from different sulfonamides and different active methylenes. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR and mass spectral data. The obtained compounds were screened as antitumor agents against human tumor cell line. Some of the tested compounds were equipotent while the others were more potent than doxorubicin (CAS 25316-40-9). The synergistic effect with gamma-radiation was also studied.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP25316409-A Doxorubicin, Hydrochloride - CAS 25316-40-9 Doxorubicin, Hydrochloride - CAS 25316-40-9 25316-40-9 Price
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