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Synthesis of Some Novel Orsellinates and Lecanoric Acid Related Depsides as

Boddu Rama Krishna, Sistla Ramakrishna, Sangaraju Rajendra, Kuncha Madhusudana, Uppuluri Venkata Mallavadhani

J Asian Nat Prod Res. 2019 Oct;21(10):1013-1027.

PMID: 29968482

Abstract:

Sixteen novel orsellinic esters (6a-l, 7a-d) along with four lecanoric acid related depsides (3a-c, 4) were synthesized and confirmed their structures by spectroscopic data (1H, 13C & HRMS). The synthesized compounds were evaluated for their in vitro α-glucosidase (Saccharomyces cerevisiae) inhibitory potential. Among the tested compounds, 3c (IC50: 140.9 μM) and 6c (IC50: 203.9 μM) displayed potent α-glucosidase inhibitory activity and found more active than the standard drug acarbose (IC50: 686.6 μM). Both the test compounds were subjected to in vivo antihyperglycemic activity using sucrose loaded model in Wistar rats and found compound 3c exhibited significant reduction in glucose levels.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AS23120 Sucrose standard for IC Sucrose standard for IC Price
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