0

Synthesis of (±)-terpendole E

Takaaki Teranishi, Tetsuro Murokawa, Masaru Enomoto, Shigefumi Kuwahara

Biosci Biotechnol Biochem. 2015;79(1):11-5.

PMID: 25184606

Abstract:

The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP167427238 Terpendole E Terpendole E 167427-23-8 Price
qrcode