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Synthesis of Two Naturally Occurring 3-methyl-2,5-dihydro-1-benzoxepin Carboxylic Acids

Seiji Yamaguchi, Nao Tsuchida, Masahiro Miyazawa, Yoshiro Hirai

J Org Chem. 2005 Sep 16;70(19):7505-11.

PMID: 16149777

Abstract:

[structures: see text] Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthesized using Stille coupling followed by Mitsunobu cyclization.

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