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Synthesis, Structural and Antimicrobial Studies of Binary and Ternary Complexes of a New Tridentate Thiosemicarbazone

Synthesis, Structural and Antimicrobial Studies of Binary and Ternary Complexes of a New Tridentate Thiosemicarbazone

Ahmed B M Ibrahim, Micheal K Farh, Jasper R Plaisier, ElSayed M Shalaby

Future Med Chem. 2018 Nov;10(21):2507-2519.

PMID: 30499339

Abstract:

A new thiosemicarbazone ligand was synthesized and characterized using spectroscopic techniques (UV-Vis and IR) and synchrotron x-ray powder diffraction. With M2+ = Mn2+, Zn2+ and Cd2+, coordination compounds of the type (M[L]2) were isolated. In the presence of sodium dithiocarbamate salts (NadiEtdtc.3H2O = sodium diethyldithiocarbamate trihydrate and Napipdtc = sodium piperidinedithiocarbamate), Zn2+ and Cd2+ were able to form ternary octahedral complexes where each metal binds a deprotonated (thiosemicarbazone) ligand, a monobasic dithiocarbamate ligand and a water molecule. In vitro biological evaluation tests of the free HL ligand and its metal complexes against selected fungal and bacterial cultures were performed. Compared with HL, the complexes displayed enhanced biological activities and ternary Zn (II) complexes displayed comparable antibacterial activities to the chloramphenicol standard.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP20624253	Sodium diethyldithiocarbamate trihydrate		20624-25-3	Price

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