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Synthesis, Structure and Antimicrobial Activity of manganese(II) and cobalt(II) Complexes of the Polyether Ionophore Antibiotic Sodium Monensin A

Synthesis, Structure and Antimicrobial Activity of manganese(II) and cobalt(II) Complexes of the Polyether Ionophore Antibiotic Sodium Monensin A

Petar Dorkov, Ivayla N Pantcheva, William S Sheldrick, Heike Mayer-Figge, Rositza Petrova, Mariana Mitewa

J Inorg Biochem. 2008 Jan;102(1):26-32.

PMID: 17692921

Abstract:

Mononuclear neutral manganese(II) and cobalt(II) complexes with the antibiotic Sodium Monensin A (Mon-Na, 1b) were synthesized and characterized. The crystal structures of M(Mon-Na)2Cl2.H2O (M=Mn, 2; M=Co, 3) were determined by X-ray crystallography. The complexes crystallize in monoclinic space group C2 with a tetrahedrally coordinated transition metal attached to oxygen atoms of deprotonated carboxyl groups of two Sodium Monensin molecules and two chloride ions. The sodium ion remains in the cavity of the ligand and cannot be replaced by Mn(II) or Co(II). The complexes were additionally characterized by different spectroscopic techniques (UV-Visible, EPR, FAB-MS). A preferable octahedral environment around the transition metal centers is observed in polar solvents while the complexes retain their tetrahedral structure in non-polar media. The antimicrobial activity of 1b, 2 and 3 was tested against Gram(+) and Gram(-) bacteria.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1258669349	Manganese(II) ionophore II		1258669-34-9	Price

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