Home
Resources
Publications
Systematic Analysis of Selective Bactericidal Activity of Fatty Acids Against Staphylococcus Aureus With Minimum Inhibitory Concentration and Minimum Bactericidal Concentration

Systematic Analysis of Selective Bactericidal Activity of Fatty Acids Against Staphylococcus Aureus With Minimum Inhibitory Concentration and Minimum Bactericidal Concentration

Takamasa Watanabe, Yoshiaki Yamamoto, Maki Miura, Hiroyuki Konno, Shigekazu Yano, Yoshimune Nonomura

J Oleo Sci. 2019 Mar 1;68(3):291-296.

PMID: 30760667

Abstract:

Bacterial flora on the skin surface contains Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) which causes rough skin and atopic dermatitis and enhances innate immunity, respectively. In this study, minimum inhibitory concentration (MIC) was evaluated for six saturated fatty acids and two unsaturated fatty acids against S. aureus and S. epidermidis. The antimicrobial behavior in the liquid medium was categorized into three groups. The first was the selective antibacterial activity group comprising myristic acid (C14:0 fatty acid), palmitoleic acid (C16:1 fatty acid), and oleic acid (C18:1 fatty acid) and preferentially displayed antimicrobial activity for S. aureus (group 1). C16:1 fatty acid displayed high antimicrobial activity only for S. aureus. The second was the non-selective antibacterial activity group which displayed antibacterial activity for both Staphylococci (group 2). Caprylic acid (C8:0 fatty acid), capric acid (C10:0 fatty acid), and lauric acid (C12:0 fatty acid) comprised group 2. The third was the nonantibacterial activity group which did not show significant antimicrobial activity (group 3). Bactericidal activities were confirmed for C12:0 fatty acid and C16:1 fatty acid by evaluating the minimum bactericidal concentration (MBC) on the agar medium. C12:0 fatty acid displayed non-selective bactericidal behavior against S. aureus and S. epidermidis when the fatty acid concentration was above 250 μg mL-1. These findings suggest that C16:1 fatty acid has the potential to be used as a detergent in skin care and medical products because it can selectively kill only S. aureus.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP108847763	1-Thianthrenylboronic acid	108847-76-3	Price
AP1218790863	2-Morpholinopyridine-3-boronic acid	1218790-86-3	Price
AP145965146	4-Bromo-1-naphthaleneboronic acid	145965-14-6	Price
AP203806080	Ethylenediaminetetraacetic-d12 acid	203806-08-0	Price
AP215527701	Phenyl-d5-boronic acid	215527-70-1	Price
AP39756326	Eicosanoic-d39 Acid	39756-32-6	Price
AP4671823	Propylenediphosphonic acid	4671-82-3	Price
AP59154437	Lauric-d23 acid	59154-43-7	Price
AP63076517	Cyclopentylboronic acid	63076-51-7	Price
AP68572872	9-Phenanthracenylboronic acid	68572-87-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: