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Systematic Review of the Use of Pentoxifylline and Tocopherol for the Treatment of Medication-Related Osteonecrosis of the Jaw

Systematic Review of the Use of Pentoxifylline and Tocopherol for the Treatment of Medication-Related Osteonecrosis of the Jaw

Jiean Joseph Heifetz-Li, Samer Abdelsamie, Conor B Campbell, Stephanie Roth, Allen F Fielding, Joseph P Mulligan

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Nov;128(5):491-497.e2.

PMID: 31488389

Abstract:

Objective:
Medication-related osteonecrosis of the jaw (MRONJ) is a pathologic process resulting in progressive destruction of the jaws. There are no established guidelines for the medical management of MRONJ. Interest in pentoxifylline and tocopherol is growing because these agents have been shown to be effective in treating osteoradionecrosis of the jaw. This review evaluates the clinical usefulness of pentoxifylline and tocopherol in treating MRONJ.
Study design:
Literature databases were searched for relevant reports of pentoxifylline and tocopherol in treating MRONJ. Only English-language reports and human studies were considered.
Results:
There were 3 published observational studies and 2 abstracts relevant to this topic. The combination of pentoxifylline and tocopherol is associated with subjective and objective improvements and no major adverse outcomes.
Conclusions:
Pentoxifylline and tocopherol has been demonstrated to be effective for managing MRONJ nonsurgically, and, thus, this treatment modality holds promise. However, larger clinical studies are needed to optimize dose and duration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6493056-A	Pentoxifylline		6493-05-6	Price

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