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Systematic Toxicity Evaluations of High-Performance Carbon "Quantum" Dots

Systematic Toxicity Evaluations of High-Performance Carbon "Quantum" Dots

Jia-Hui Liu, Yanli Wang, Gui-Hua Yan, Fan Yang, Haidi Gao, Yanan Huang, Haifang Wang, Ping Wang, Liju Yang, Yongan Tang, Lindsay Rose Teisl, Ya-Ping Sun

J Nanosci Nanotechnol. 2019 Apr 1;19(4):2130-2137.

PMID: 30486956

Abstract:

Carbon dots (CDots) in a general structure of small carbon nanoparticles with various surface passivation schemes have emerged to represent a new class of carbon nanomaterials in now a rapidly advancing and expanding research field. Among various synthesis methods, the use of pre-processed and selected small carbon nanoparticles for deliberate chemical functionalization of the particle surface with organic molecules have produced high-performance and structurally better defined CDots. Specifically, small organic molecules 2,2'-(ethylenedioxy)bis(ethylamine) and 3-ethoxypropylamine were used for the effective surface passivation of the carbon nanoparticles via chemical functionalization to yield CDots that are brightly fluorescent and also structurally ultra-compact, amenable to various desired cell imaging applications. Thus, a systematic evaluation of these CDots on their cytotoxicity profiles is necessary, and performed in this study by using a diverse selection of cell lines. Also for fluorescence imaging, CDots were modified with their encapsulating selected organic dyes for much enhanced red/near-IR fluorescence emissions. These modified CDots with the dyes as guest were also evaluated for their cytotoxicity profiles. The results suggest that the CDots without and with the guest dyes are generally nontoxic to the selected cell lines, further supporting the notion that CDots can be used as high-performance yet nontoxic bioimaging agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6291856	3-Ethoxypropylamine		6291-85-6	Price

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