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t-Butyloxycarbonyl: An Ordinary but Promising Group for Protecting Peptides From Deiodination

t-Butyloxycarbonyl: An Ordinary but Promising Group for Protecting Peptides From Deiodination

Xin Sun, Taiwei Chu, Xinqi Liu, Xiangyun Wang

Appl Radiat Isot. 2006 Jun;64(6):645-50.

PMID: 16488150

Abstract:

In order to protect directly radioiodinated peptides from in vivo deiodination, a novel procedure was explored. Two peptides, Try-Gly-Gly-Gly-Gly-Gly-Cys-Asn-Gly-Arg-Cys (YG5) and t-Boc-Try-Gly-Gly-Gly-Gly-Gly-Cys-Asn-Gly-Arg-Cys (t-BOC-YG5) were synthesized and radiolabeled. A paired-label biodistribution study using [131I]t-BOC-YG5 and [125I]YG5 was undertaken in normal mice. Compared to [125I]YG5, [131I]t-BOC-YG5 was quite resistant to in vivo deiodination, resulting in rapid reduction of the radioactive background and negligible radioactivity accumulation in both thyroid and stomach. [131I]t-BOC-YG5 was also stable in human serum even after 24 h. In conclusion, the t-BOC group has the potential to protect peptide from deiodination.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7093676	Gly-Gly-Gly-Gly-Gly		7093-67-6	Price

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