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Takotsubo Cardiomyopathy With Transient Left Ventricular Obstruction Successfully Treated With Cibenzoline Succinate: A Case Report

Takotsubo Cardiomyopathy With Transient Left Ventricular Obstruction Successfully Treated With Cibenzoline Succinate: A Case Report

Katsuhiro Tomofuji, Shuntaro Ikeda, Chika Murakami, Yusuke Ochiumi, Masayuki Nakamura, Hisaki Kadota, Hideaki Shimizu, Kiyotaka Oshima, Mareomi Hamada

J Cardiol Cases. 2015 Mar 24;11(6):155-157.

PMID: 30546553

Abstract:

An 84-year-old woman was urgently referred to our hospital owing to persistent malaise and chest pain. Takotsubo cardiomyopathy was diagnosed following transthoracic echocardiography, emergency coronary angiography, and left ventriculography. A left ventricular pressure tracing during cardiac catheterization revealed a 72 mmHg-intraventricular pressure gradient (LVPG). Although β-blockers are effective at reducing LVPG in takotsubo cardiomyopathy, such treatment was contraindicated in our patient owing to her history of bronchial asthma. Therefore, we administered intravenous cibenzoline succinate to attenuate her LVPG. The LVPG decreased to 18 mmHg within 10 min after intravenous cibenzoline succinate administration. During her subsequent hospitalization, the patient showed excellent functional recovery, without any complications. Left ventriculography, performed 21 days after admission, showed normal wall motion and a left ventricular ejection fraction of 68%. .

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP100678328	Cibenzoline succinate		100678-32-8	Price

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