Home
Resources
Publications
Tanshinone I Inhibits the Growth and Metastasis of Osteosarcoma via Suppressing JAK/STAT3 Signalling Pathway

Tanshinone I Inhibits the Growth and Metastasis of Osteosarcoma via Suppressing JAK/STAT3 Signalling Pathway

Weiguo Wang, Jinsong Li, Zhiyu Ding, Yuezhan Li, Jianlong Wang, Shijie Chen, Jinglei Miao

J Cell Mol Med. 2019 Sep;23(9):6454-6465.

PMID: 31293090

Abstract:

Tanshinone I (Tan I) is a widely used diterpene compound derived from the traditional Chinese herb Danshen. Increasing evidence suggests that it exhibits anti-cancer activity in various human cancers. However, the in vitro and in vivo effects of Tan I on osteosarcoma (OS) remain inadequately elucidated, especially those against tumour metastasis. Our results showed that Tan I significantly inhibited OS cancer cell proliferation, migration and invasion and induced cell apoptosis in vitro. Moreover, treatment with 10 and 20 mg/kg Tan I effectively suppressed tumour growth in subcutaneous xenografts and orthotopic xenograft mouse models. In addition, Tan I significantly inhibited tumour metastasis in intracardiac inoculation xenograft models. The results also showed that Tan I-induced increased expression of the proapoptotic gene Bax and decreased expression of the anti-apoptotic gene Bcl-2 is the possible mechanism of its anti-cancer effects. Tan I was also found to abolish the IL-6-mediated activation of the JAK/STAT3 signalling pathway. Conclusively, this study is the first to show that Tan I suppresses OS growth and metastasis in vitro and in vivo, suggesting it may be a potential novel and efficient drug candidate for the treatment of OS progression.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP568730	Tanshinone I		568-73-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: