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Targeting Calcium Signaling in Cancer Therapy

Targeting Calcium Signaling in Cancer Therapy

Chaochu Cui, Robert Merritt, Liwu Fu, Zui Pan

Acta Pharm Sin B. 2017 Jan;7(1):3-17.

PMID: 28119804

Abstract:

The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+ homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research into the understanding of cellular mechanisms underlying the regulation of Ca2+ signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca2+ channels or transporters.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25371964	1-[2-(Trifluoromethyl)phenyl]imidazole		25371-96-4	Price

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