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Targeting HSP90 to Halt Neurodegeneration

Kathleen A Gallo

Chem Biol. 2006 Feb;13(2):115-6.

PMID: 16492558

Abstract:

Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP63735717 AEG 3482 AEG 3482 63735-71-7 Price
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