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Targeting IL-10 Family Cytokines for the Treatment of Human Diseases

Targeting IL-10 Family Cytokines for the Treatment of Human Diseases

Xiaoting Wang, Kit Wong, Wenjun Ouyang, Sascha Rutz

Cold Spring Harb Perspect Biol. 2019 Feb 1;11(2):a028548.

PMID: 29038121

Abstract:

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating immune responses during host defense but also in autoimmune disorders, inflammatory diseases, and cancer. Although IL-10 itself primarily acts on leukocytes and has potent immunosuppressive functions, other family members preferentially target nonimmune compartments, such as tissue epithelial cells, where they elicit innate defense mechanisms to control viral, bacterial, and fungal infections, protect tissue integrity, and promote tissue repair and regeneration. As cytokines are prime drug targets, IL-10 family cytokines provide great opportunities for the treatment of autoimmune diseases, tissue damage, and cancer. Yet no therapy in this space has been approved to date. Here, we summarize the diverse biology of the IL-10 family as it relates to human disease and review past and current strategies and challenges to target IL-10 family cytokines for clinical use.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248648	IL-10 human			Price

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